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A., Murk, W

Prolonged use of Vitamin B6 (over 2 months) at high doses exceeding 1g/day can lead to severe peripheral neuropathy, with symptoms including unsteady gait and numbness in the hands and feet

Yes, nausea, vomiting, diarrheathese are not uncommon side effects

Patients should contact their GP or diabetes team if they experience: Severe, persistent abdominal pain (potential pancreatitis) Persistent vomiting leading to dehydration Signs of hypoglycaemia (if taking alongside insulin or sulphonylureas) Severe or persistent constipation or abdominal distension Right upper quadrant pain, fever or jaundice (potential gallbladder problems) Sudden visual changes (especially in those with diabetic retinopathy) Allergic reactions or injection site problems Weight loss typically becomes noticeable within the first few weeks to months, though the rate varies considerably between individuals

Here is the challenge with semaglutide

Patients who had taken Novos new CagriSema, a shot that combines semaglutide with an analog of another hormone, had slimmed down by 22.7 percent