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The zinc Ionophore Clioquinol reduces Parkinsons disease patient-derived brain extracts-induced neurodegeneration
Strategies such as HDAC inhibition, astrocyte transplantation and modulation of autophagy or metabolic pathways remain confined to experimental models, whereas GLP-1 receptor agonists and MAO-B inhibitors have advanced to clinical testing and show effects on astrocytic metabolism and neuroinflammation
Additionally, in a phase I study, treatment of cagrilintide (up to 4.5 mg) combined with semaglutide (2.4 mg) resulted in greater body weight reduction than semaglutide (17% vs
Recently, a surfactant conjugated co-agonist peptide 17 was shown to have a half-life of 52 hours in vivo and at a higher dose led to 40% body weight loss in obese rats over 27 days ( Table 1 )
J Trials 21, 633 (2020)
Carlat Verdict: The GLP-1 agonists are potential game changers for the treatment of antipsychotic weight gain
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