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However, loss of DJ-1 promotes the dissociation between p65 and NF-B inhibitor (IB), facilitating p65 nuclear translocation, resulting in more microglial activation and aggregation of microglia-mediated neurotoxicity in an NF-B-dependent manner [137]

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For example, Kras G12D released from autophagy-dependent ferroptotic cancer cell death can limit the antitumour effects of macrophages by activating STAT3-mediated AGER-dependent M2 macrophage polarization [114]

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A 2019 study monitored 33 people with overweight or obesity

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