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It says people with a personal history of pancreatitis, medullary thyroid cancer, multiple endocrine neoplasia type 2, or severe dehydration should avoid GLP-1 therapy or use it only under close specialist supervision

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These findings underscore semaglutides role as a rescue intervention rather than a preventive measure and support the exploration of early hormonal monitoring and anatomical surveillance as possible tools for identifying high-risk individuals (Table 7), acknowledging that further validation is warranted

Although it is not yet available, the manufacturer, Novo Nordisk, filed for FDA approval in December 2025, with FDA review expected in 2026

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