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TCF7L2 is a possible regulator of GLP-1 receptor expression in human vascular cells Since there was correlation between the expression levels of GLP-1 receptor and TCF7L2 in the aorta in our experiments and it is well known that TCF7L2 is a transcriptional factor of GLP-1 receptor in pancreatic -cells, we hypothesized that TCF7L2 regulates GLP-1 receptor expression in human vascular cells as observed in -cells
In addition to its metabolic effects, GLP-1 acts centrally to maintain energy balance by activating glucagon-like peptide-1 receptors (GLP-1Rs) located in key regions of the brain
RNA-Seq data from 2 different cohorts (SARP and IMSA [GSE 158752]) were analyzed
In order to enhance the clinical interpretation of these CVOTs, researchers have quantified the absolute treatment effect over time based on the number of treatments required to avoid a MACE, thus revealed the difference between GLP-1RA [175]
Clinical trials have shown that individuals can lose an average of approximately 50 pounds
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