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A patient starts with oral drops to experience the appetite suppression and confirm they tolerate the medication
Patients with a personal or family history of certain thyroid cancers should not use any dose of semaglutide
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10.1097/HEP.0000000000000323 Hepatology
In a meta-analysis 6 of eight trials with 60080 patients (ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony Outcomes, REWIND, PIONEER 6, and AMPLITUDE-O) , treatment with a GLP-1 receptor agonist led to a 14% relative risk reduction in three-point MACE (HR 086 [95% CI 080093]
Changing two variables at once makes it impossible to attribute any adverse effect to either agent
