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The MDM2 inhibitor nutlin-3a suppresses abnormal T-cell expansion and reduces systemic inflammation in SLE models, highlighting an immunoregulatory role for MDM2 inhibition beyond oncology
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10.1152/japplphysiol.01132.2017 43 SprietL
About the Author and Review About the Author : Ed Van Harmelen is the founder of Youth & Earth and a passionate advocate for biohacking and anti-aging since 2017
In the multicenter PIVENS ( PI oglitazone versus V itamin E versus placebo for the treatment of N onalcoholic S teatohepatitis) trial, 247 subjects with MASH but not diabetes mellitus were randomized to receive 30 mg/day of pioglitazone (an insulin-sensitizing drug), 800 IU/day (536 mg/day) of RRR --tocopherol, or a placebo for 96 weeks (97)
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