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The FDA considers 5% weight loss clinically meaningful, and a drug must demonstrate a statistically significant advantage over placebo on this categorical measure
The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-/, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH)
PMID 1658407
We have these kidney, heart, and lifesaving therapies, [but] how do we get them to the people who can benefit
227 Heteroplasmy is present in most healthy individuals without leading to mitochondrial disease
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