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doi: 10.17849/insm-51-3-1-20.2 59
Most of the GLP-1 medications work only on the GLP-1 receptor
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The debate over GLP-1s isnt just medical, its political
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It also creates a feedback loop IGF-1 and GH both feed back on the hypothalamus and pituitary to restrain further GH release, principally by promoting somatostatin tone
Glutathione tackles this at a biological level by: Inhibiting tyrosinase activity to slow down melanin production Shifting melanogenesis from eumelanin (darker) to pheomelanin (lighter) Acting as an antioxidant to reduce the oxidative stress that triggers hyperpigmentation A 2025 systematic review in the International Journal of Dermatology confirms that oral glutathione at doses of 250 mg twice daily and 500 mg once daily showed a significant reduction in melanin index compared to placebo, particularly in sun-exposed areas like the face and wrists
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