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While there was a substantial increase over the ten-year period between 2012 and 2022, some evidence indicates that utilization has only continued to rise over the last two years, beyond the most recent claims data available

10.1681/ASN.2013101068 39 DongW.LiZ.ChenY.ZhangL.YeZ.LiangH.et al (2018)

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The abundance of erythrocytes in circulation suggests that immunogenic consequences of their cell death might dictate the immune response in disease, which is an underappreciated but important feature of erythrocyte biology

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