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226 Aberrant sialylation can promote CD4 + T-cell activation, leading to the occurrence of UC, while deficiency of the -2,6-sialyltransferase ST6GAL1 inhibits the process of sialylation and limits CD4 + T cell activation by suppressing the expression of NF-B, subsequently decreasing the production of proinflammatory cytokines and alleviating UC

Since then, MET levels remain elevated in the neocortex, hippocampus, and sub-cortical limbic regions of mice forebrains during the second post-natal week, decreasing from P21 to adult age ( striatum radiatum layer of hippocampal CA1 region are comparable in pre- and post-synaptic terminals at P7 peak in mouse

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Mayo Clin Proc 2004