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While some studies have found silymarin to be well tolerated with low side-effects 3 , individual reactions and side effects can vary
However, each metabolic intermediate in the DNL pathway (i.e., citrate, acetyl-CoA, malonyl-CoA, and palmitate) also has second messenger functions
It is possible that rhein relieves APAP-induced liver injury through inhibiting the activity of P450 enzymes
Phytomedicine 116, 154825
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