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Metformin) with diagnosis of type 2 diabetes Documented history of lifestyle intervention Quarterly clinical review to assess improvement (weight loss or A1C) Discontinuation if there is no measurable improvement after 6 months 3

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First described in 2015, MOTS-c was discovered to circulate in the bloodstream and influence key metabolic pathways, particularly those tied to energy balance and glucose control

Modern weight management medications, such as semaglutide and tirzepatide, are highly effective at facilitating weight loss and are prescribed to large numbers of people, both privately and on the NHS, in the UK

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