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2019), and it also provides evidence for the deficiency of protease activity in the loss-of-function mutant form of hHPN RS

"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams." Archives of dermatology 131.9 (1995): 1037-1044

The overall worst phase for most patients is weeks 58 coinciding with the first dose escalation to 0.5 mg

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Increases glutathione reserves