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Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3
It is essential for the regulation of a variety of cellular activities, protein function, and DNA synthesis
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In other words, glutathione also protects the cell from the outside, not simply from ROS forming on the inside of the cell
The ATP-binding cassette (ABC) transporters, including P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), expressed on the luminal endothelial plasma membrane, are pivotal in CNS pharmaco-resistance [24, 30,31,32]
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