Most patients report SubQ as virtually painless when technique is correct, whereas IM commonly produces discomfort lasting 1224 hours
Potential clinical consequences include: Development of anti-drug antibodies (ADAs) Reduced therapeutic efficacy Altered pharmacokinetics Injection-site reactions or systemic hypersensitivity Regulators therefore place strong emphasis on impurity profiles that could increase immunogenic potential beyond that of the Reference Listed Drug (RLD) Impurity Attributes That Increase Immunogenic Risk Not all impurities pose equal immunogenic concern
R., Ballesteros, J., and Tejada, M
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PMID 8331657
If the solution under the foam is cloudy, the peptide may have been denatured by the force