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Intravenous NR or NMN administration in mice results in rapid conversion into circulating NAM and NAD + boosting in liver, kidney, skeletal muscle, while NAD + in these organs after oral administration increases to a lower magnitude 39,69

The concomitant use of topiramate with other carbonic anhydrase inhibitors or in patients on a ketogenic diet may create a physiological environment that increases the risk of kidney stone formation and should therefore be avoided

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The optimal timing strategy varies accordingly