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Risks of hCG include headaches, depression, acne, hair loss, breast tenderness and, in more rare cases, blood clots that can be fatal if they travel to the lungs, Ransom said

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Once anesthetized, the right knee joints of the animals were shaved, sterilized, and subjected to an intra-articular injection of collagenase type II

The biological plausibility of AOD9604s cartilage-regenerating effects is further supported by insights from conditions such as acromegaly, where excess GH leads to abnormally thick cartilage due to elevated local IGF-1 production