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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
That logic works for something like fentanyl, where decades of data tell us exactly how dangerous the status quo is test strips and safer supply reduce a known, measured risk
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IGF-1 levels rise downstream, and visceral adipose tissue decreases in studies ranging from short-term rodent protocols to 52-week human trials
Similar to its analgesic action, the mechanism of antipyretic action of this drug remains poorly understood
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