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The key clinical evidence comes from the OASIS 4 trial, a 71-week phase 3 randomised controlled trial in which 307 adults without diabetes, with a BMI of 30 or above (or 27 or above with at least one weight-related health condition), were assigned to either oral semaglutide 25mg or placebo, alongside lifestyle intervention

Over the last few years, novel non-steroidal MRAs such as finerenone have been developed that demonstrate greater mineralocorticoid receptor selectivity and other pharmacokinetic differences compared with steroidal MRAs [67]

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doi:10.1016/s2213-8587(15)00482-9

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