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If you want to check the science yourself rather than take a clinics word for it, review the peer reviewed medical literature indexed in the National Institutes of Health PubMed Central library explaining why large peptide molecules resist passive absorption through intact skin without specialized delivery systems

You can think of them as smaller and simpler versions of proteins, which are made of longer chains of amino acids

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The potency of PF-06882961 (CS EC 50 = 13 nM) on the cAMP pathway was approximately 120- and 14-fold (Fig 3A, Table S2) lower than exenatide (CS EC 50 = 0.11 nM) and liraglutide (CS EC 50 = 0.95 nM), respectively

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