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Danazol, a synthetic steroid with antigonadotropic and anti-estrogenic properties was the first FDA-approved treatment for endometriosis, but its use has been restricted in some regions due to safety concerns around liver toxicity and androgenic and teratogenic side-effects

[7] In the 1980s, the University of Arizona synthesised more potent analogs of a-MSH, including afamelanotide

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