The hyperglycemia-induced downregulation of GLP-1R is involved in NF-B activation and the subsequent inflammatory response in mesangial cells (Zhou et al., 2014)
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This builds on his work to understand 'how circulating GLP-1 can produce multiple actions, both directly and indirectly, on multiple organs' which he has pursued for many years with colleagues (McLean, Wong, Campbell)
Studies measuring biochemical markers of muscle damage reveal that L-Carnitine reduces myoglobin levels immediately post-exercise (weighted mean difference: -11.55 ng/mL, p=0.04) and at 30-60 minutes (weighted mean difference: -41.09 ng/mL, p=0.001), as well as creatine kinase (CK) at 2 hours (weighted mean difference: -26.72 IU/L, p=0.02) and 24 hours (weighted mean difference: -48.72 IU/L, p=0.006) following exercise