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Since PAI-1 exists in significant excess relative to tissue plasminogen activator (tPA) in plasma, even modest reductions could meaningfully improve the body ability to clear clots

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To explore the underlying mechanism of SP@M in alleviating RA, the synovium and proliferated inflammation tissue around the joints in upper limbs in the saline group and SP@M group were isolated, respectively, for RNA sequencing analysis (Supplementary Fig