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The greater amount of heterogeneity of cell size in HSL null mice is exaggerated in mice with combined HSL and leptin deficiency, with a marked increase in small, lipid-devoid cells that appear to have characteristics of pre-adipocytes [14]

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MedlinePlus Encyclopedia : 003479 "Harmonisation of Reference Intervals" (PDF)

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However, the most profound metabolic changes occur during the titration phase between weeks 12 and 24