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Its a combination of things
The reported side effects appear to be similar to those reported with sermorelin [6]
Benmimoun B, Polesello C, Waltzer L, Haenlin M
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One compound, CBR-5884, inhibits PHGDH by interacting with its substrates NADH and 3-phosphoglycerate (3-PG) in a non-competitive, time-dependent manner, destabilizing the enzymes tetrameric form and converting it into a dimer
Senescent fibroblasts exhibit higher expressions of Bcl-2, conferring resistance to apoptosis [22]
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