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Surgery = One Procedure, Long-Term Benefits Bariatric surgery may have a higher upfront cost, but unlike GLP-1 medications, it: Does not require lifelong dosing Produces more durable, effective weight loss Reduces long-term healthcare costs by improving diabetes, blood pressure, sleep apnea, and more Conclusion: Bariatric surgery is both MORE effective and LESS expensive than long-term GLP-1 therapy

Otherwise low toxicity water-soluble

Fertil Steril (2007) 88(6):17035

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These drugs are currently FDA-approved for type 2 diabetes and obesity not for alcohol use disorder

While it is available as a research chemical, it is not approved for injection in humans