This activated YAP then promotes the transcriptional induction of ATF4, which plays a role in the expression of genes involved in amino acid homeostasis, including Sestrin2
Composed of three amino acids - cysteine, glutamic acid, and glycine - this tripeptide plays a crucial role in various bodily functions
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This distinction was explored in a study where the Ex4-induced decline in alcohol drinking was blunted in central GLP-1R knockout mice, whereas the effect of Ex4 remained intact after peripheral GLP-1R knockout (Figure 2) ( FIGURE 2 On this note, Ex4 introduction into the NTS lowers alcohol drinking in male rats ( via NTS to regulate alcohol responses