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Both Ozempic and Rybelsus have been demonstrated to induce weight reduction in individuals diagnosed with type 2 diabetes
The relationship between dose and response in humans is unknown
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Our results uncover a new noncanonical function of PKM2 as a transcriptional coactivator of Nrf2, which cooperates with its metabolic function to divert glucose flux into the pentose phosphate pathway 55 and thereby generates sufficient GSH for ROS detoxification
C., Horwitz, B
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