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Evidence from cells and animals can show a research signal
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Taken together, FOXO4-DRI is able to remove the senescent cells in PDL9 chondrocytes, but its utility in promoting cartilage formation from the in vitro expanded chondrocytes needs further investigation
To systematically evaluate the pathways driving this sensitivity, we performed continuous gene set enrichment analysis (GSEA) ranking all mapped genes by their Pearson correlation coefficient ( R ) between basal expression (log 2 (TPM + 1)) and the PRISM log 2 (fold de-enrichment) across the 470 matched cell lines (note that 5 cell lines were not listed on HPA and were therefore not included
J Clin Invest 101(5):1012-9, 1998
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