In addition, the British National Formulary offers the following advice: Important: When prescribing an antipsychotic for administration on an emergency basis, the intramuscular dose should be lower than the corresponding oral dose (owing to absence of first-pass effect), particularly if the patient is very active (increased blood flow to muscle considerably increases the rate of absorption)
Ethics declarations Conflict of Interest FG Eliaschewitz and D R Franco reports consulting fees from Eli Lily, NovoNordisk, AstraZeneca, and Sanofi-Aventis
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Yes, certain medications including corticosteroids, atypical antipsychotics, and some hormonal therapies can promote weight gain or worsen insulin resistance, potentially counteracting tirzepatide's benefits