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There are some data to suggest that insulin resistance also occurs in PD [70], however, this is controversial since systemic insulin resistance is not present in de novo, medication-free PD patients [71], and brain insulin resistance is not present in cognitively normal PD cases [72]
Hubert C
More severe side effects are rare but can include an allergic reaction or the development of blood clots
For example, in December 2024, the FDA approved Zepbound for the treatment of sleep apnea
The efficacy of tirzepatide in attaining a 1520% reduction in weight while preserving gastrointestinal tolerability illustrates that this equilibrium is attainable, although necessitating advanced drug design (Tuttle et al
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