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Activation of G protein-coupled bile acid receptor, TGR5 induces muscle relaxation via PKA- and Epac-mediated inhibition of RhoA/Rho kinase pathway
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Fasted mice were orally-gavaged with the indicated compound(s), and 3-hours later, were subjected to an oral-glucose-tolerance-test (OGTT)
Patients average BMI dropped from 43.1 to 41.5, and the average weight decreased from 117.7 kg to 111.6 kg
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