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An NIH systematic review on triple agonism-based obesity therapies provides further context, confirming that retatrutides phase 2 dataset remains the most extensive published for any triple agonist to date
LDL-P and Lp(a) can reveal residual risk that standard panels miss, especially in metabolically active or athletic populations
The authors note that semaglutide could be combined with SGLT2 inhibitor therapy to provide additional nephroprotective benefits.
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Whenever feasible, continuation of GLP1 RA therapy may be considered
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