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Transition plan to insulin / discontinuing GLP-1 RA
Tirzepatides renal outcomes trial is ongoing
It targets GIP, GLP-1, and glucagon pathways
Studies show it affects over 4,000 human genes, with 70% of changes promoting tissue healing and regeneration (Campbell et al., BioMed Research International, 2012)
The mean time to intensification of treatment with insulin was 7.1, 6.1 and 6.0 years for those taking one, two or three oral drugs
Recent analytical studies have detected toxic metals and metalloids (e.g., Pb, Cd, Hg, As, and Cr) in certain marine collagen products, underscoring the need for stringent quality control, traceability od sources, and regulatory oversight throughout the production process [89]
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