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What was studied: Cardiovascular death and worsening of heart failure over a median follow-up of roughly two years Outcome: Tirzepatide reduced the combined risk of cardiovascular death and worsening heart failure events by approximately 38%, driven largely by a 46% reduction in worsening heart failure events requiring hospitalization or urgent care
GLP1RAs were significantly associated with an increased risk of DVT (OR, 1.64 [95% CI, 1.142.36])
The GHR antagonist pegvisomant is an analog of GH that competes with GH for receptor binding and consequently blocks GHR signal transduction
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"The main way GLP-1 medications work for weight loss is at the gut to make you feel full and at the brain to make you less hungry," says Carolynn Francavilla, M.D., MFOMA, DABOM