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Peer review Peer review information Nature Communications thanks Chengyong Tang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Many are comparing copper-peptide signaling against other remodeling agents already in their pipeline, choosing a spray format because it simplifies blinding and dose standardization across a treatment group

PlexusDx helps patients navigate these interactions safely while pursuing personalized GLP-1 therapy

Carlson Labs 17.8

Results We included 1,647,238 patients who were prescribed a GLP-1 RA between January 2024 and July 2025, with 6,059,445 total GLP-1 RA prescriptions during this period

These results coincide with a previous study showing that the anti-inflammatory effect of berberine involves Nrf2 activation and that the role of berberine as an anti-inflammatory agent is dependent on Nrf2 in a systemic acute inflammation mouse model [107]