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A narrative review was conducted based on a literature search for randomised controlled trials, cohort studies, case reports, and systematic reviews reporting outcomes of GLP-1 RAs therapies in SIH and SID
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Even Distribution: Gently apply the ampoule to your face, distributing it evenly across your skin
Tirzepatide works primarily through appetite modulation via GIP and GLP-1 receptor agonism
not yet FDA-approved for any population Best adult efficacy / 24.2% mean weight loss at 48 weeks (12 mg dose, Phase 2) [1] Adolescent trial data / none published as of May 2026 Primary safety signals in adults / nausea, diarrhea, vomiting, decreased appetite [1] Growth concern / caloric restriction during puberty may slow linear growth velocity Mental-health watch / depression, suicidal ideation screening recommended per FDA adolescent obesity guidance Comparator precedent / semaglutide 2.4 mg studied in STEP TEENS (ages 12, 17) with a similar GI side-effect profile [2] Monitoring minimum / Tanner staging, height velocity, bone-age films, PHQ-A at each visit Why Adolescent Safety Data for Retatrutide Does Not Yet Exist No peer-reviewed trial has enrolled patients aged 12 to 17 for retatrutide as of May 2026
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