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They still gained weight, especially around the midsection

Others who have already undergone bariatric surgery may use medications to strengthen appetite control and overcome late-stage weight plateaus

The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]

Polymer-based, lipid-based, and inorganic nanoparticles, as well as extracellular vesicles, have been used to deliver miRNAs that target key resistance pathways