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These trials showed that tirzepatide reduced fasting plasma glucose and HbA 1c levels not only compared with placebo but also compared with the insulins degludec and glargine or semaglutide [90,91,92]

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Patients in whom heart failure (HF) or chronic kidney disease (CKD) is prevalent, should receive a treatment intensification with an SGLT-2 inhibitor with the respective evidence from clinical studies due to the respective data (7072)

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Can.J Public Health 2008;99(4):276-280

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