Triple agonists combining GLP 1, GIP and glucagon receptor activity represent another frontier with early data suggesting these may produce even greater weight loss and metabolic improvements
They exhibit distinct and yet several similar physiological actions including suppression of food intake, postprandial glucagon secretion, and gastric emptyingaltogether lowering plasma glucose and body weight
The receptors each compound targets determine its entire profile of benefits and limitations
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[PubMed] Goldstein BJ, Mahadev K, Wu X (2005) Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets
Wills J, Jones J, Haggerty T, Duka V, Joyce JN, Sidhu A