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These are drugs that may be expensive or may require help from healthcare professionals to be used safely and effectively

Around 86% of participants achieved at least 5% weight loss, and about a third lost 20% or more

Mechanism of Action IGF-1 LR3 and IGF-1 both bind to IGF-1 receptors, the stimulation of which activates pathways, including PI3K/AKT and MAPK, to bring about the following effects: Promotion of glucose uptake and subsequent utilisation Increase in energy production in cells Enhancement of glycolysis Increased protein and lipid synthesis Coordination of nutrient uptake Increase in cell proliferation and differentiation Changes in gene expression that support cell cycle progression and tissue growth

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Trivedi MS, et al

Female sex is widely recognized as an independent factor associated with greater BW loss achievement following treatment with GLP-1 RAs, a superiority observed in the majority of studies [47, 48]