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In phase 3 clinical trials, participants using semaglutide (2.4 mg once weekly) showed 10-15% body weight reduction on average after 68 weeks
Semaglutide-mediated protection against Abeta correlated with enhancement of autophagy and inhibition of apotosis
Conclusions GLP-1 agonists reduce fetal survival, weight, growth and skeletal ossification and can induce major congenital anomalies
Originally developed as diabetes medications, new glucagon-like peptide-1 (GLP-1) medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Zepbound, Mounjaro) suppress a patients appetite, slow gastric emptying, and help the pancreas increase its production of insulin to regulate blood sugar
This is one reason why overall diversity can decrease even as certain beneficial species increase
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