Financial support This research received no specific grant from any funding agency, commercial, or not-for-profit sectors
Its approval rests on two multicenter, randomized, double-blind, placebo-controlled trials in patients with erythropoietic protoporphyria one conducted in Europe and one in the United States in which the afamelanotide implant increased the amount of pain-free time patients could spend in sunlight and was generally well tolerated, with adverse events that were mostly mild
Zhang S, Xu M, Liu Z-J, Feng J, Ma Y
Avoid guessing dosage to prevent unwanted concentration variations
a Japanese single-center, retrospective study
Subsequently, the significance of the values in all cases was analyzed by one-way repeated measures analysis of variance followed by a TukeyKramer multiple comparisons test (GraphPad InStat