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If the amino acid glycine is present at high concentrations, -glutamylcysteine is converted in small amounts to pyroglutamic acid that can be recycled to form glutamate
Accordingly, excess DPP-4, derived from adipocytes and/or hepatocytes, may act as a local mediator of inflammation and adipose/hepatic tissue insulin resistance, thereby forming one link between obesity and the pathogenesis of T2DM and metabolic disease (Figure 3)
Glycocalyx repair and endothelial protection The endothelial glycocalyx is crucial for maintaining vascular integrity, and its degradation after aSAH promotes inflammation, microthrombosis, and impaired NO production
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