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However, this same mechanism can lead to various gastrointestinal side effects that are among the most commonly reported adverse reactions

C3/C2 = propionyl-CoA carboxylase (elevated in propionic/methylmalonic acidemia)

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The study had two objectives: to demonstrate PF3944 could achieve continued weight loss when switching from weekly to monthly subcutaneous injections and maintain its efficacy while reducing the dosing frequency four-fold and to demonstrate PF3944 could switch to a four-fold equivalent monthly dose while maintaining a well-tolerated and favorable safety profile

This lets GSH give away a hydrogen to fight free radicals, something GSSG can't do