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Studies that have measured GDH activity and exogenous glutamate use in primary neuronal cultures from the rat ventral mesencephalon have shown that GDH activity is approximately four times higher in mature (12-day-old) cultures than in immature (4-day-old) cultures and have identified a significant correlation between exogenous glutamate use (added to the medium at 1.2 mM) and GDH activity in cultured cells ( GDH in the ageing brain Developmental synaptic pruning, which is essential for honing neurons, progressively results in cumulative, nonpathological synaptic degradation over time, which has an irreversible effect on all maturing organisms

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Cellular mechanisms of melatonin action [PMID: 9674691] Laboratory literature summary: Cellular mechanisms of melatonin action

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