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doi: 10.1093/humupd/dmx016 159 ChenCZhouYHuCWangYYanZLiZet al

Despite some positive effects of GSH pretreatment on resistance of old myocardium to I/R, the improvement of heart function recovery was not observed in the late period of reperfusion that may indicate exhausted intrinsic antioxidant reserves of the myocardium, so further studies are needed for the investigation of long-term increase of myocardial resistance to I/R

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Still, this highly reactive metabolite is conjugated to the nucleophile, reduced glutathione (Bertolini et al

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Brazilian J Dev