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The initial step in the MD workup was examination for mtDNA gene abnormalities by either a targeted analysis for common mutations and/or deletions and/or sequencing of the entire mtDNA genome (Baylor Medical Genetics Laboratory, Houston, TX, USA)
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What are the before-and-after results
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On induction with interferon- (IFN-), the constitutive 1, 2 and 5 subunits of 20S proteasome are replaced by catalytically active inducible 1i (PSMB9), 2i (PSMB10) and 5i (PSMB8) subunits referred as the immunoproteasome 24,25