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Establish a systematic rotation pattern, such as: Week 1: Right abdomen Week 2: Left abdomen Week 3: Right thigh Week 4: Left thigh Week 5: Right upper arm Week 6: Left upper arm Week 7: Return to right abdomen This approach ensures each site receives adequate recovery time between injections
Cagrilintide may offer a slightly better tolerability profile with more predictable side effect patterns, though this is based on comparative analysis rather than head-to-head trials
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However, long-term pramlintide treatment is limited by low bioavailability and the short half-life of the drug, which makes it less suitable for chronic therapy due to the high administration frequency (two to three times daily) and therefore high compliance-related demands
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